Oncogenetics
Studies from P. Muller and colleagues yield new information about oncogenetics
Published in Cancer Weekly, August 26th, 2008
According to a study from Brno, Czech Republic, "p53 missense mutant proteins commonly show increased stability compared to wild-type p53, which is thought to depend largely on the inability of mutant p53 to induce the ubiquitin ligase MDM2. However, recent work using mouse models has shown that the accumulation of mutant p53 occurs only in tumour cells, indicating that stabilization requires additional factors."
"To clarify the stabilization of p53 mutants in tumours, we analysed factors that affect their folding and degradation. Although all missense mutants that we studied are more stable than wild-type p53, the levels correlate with individual structural...
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Source: Cancer Weekly (2008-08-26)
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