Cancer Weekly
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Angiogenesis
Research on angiogenesis discussed by scientists at St. Thomas' Hospital
August 26th, 2008
"Combretastatin-A4-phosphate (CA4P) acts most effectively against immature tumour vasculature. We investigated whether histological angiogenic profile can explain the differential sensitivity of human tumours to CA4P, by correlating the kinetic changes demonstrated by dynamic MRI (DCE-MRI) in response to CA4P, with tumour immunohistochemical angiogenic markers," scientists in London, the United Kingdom report. "Tissue was received from 24 patients (mean age 59, range 32-73, 18 women, 6 men). An angiogenic profile was performed using standard immunohistochemical techniques. Dynamic MRI data were obtained for the same patients before and 4 h after CA4P. Three patients...
Source: Cancer Weekly (2008-08-26)
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