Cancer Weekly
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Cancer Vaccines
Study findings on cancer vaccines are outlined in reports from Army
September 2nd, 2008
" HER-2/neu is overexpressed in breast cancer and is the source of immunogenic peptides. CD4(+) T-helper peptides for HER-2/neu are being evaluated in vaccine trials," researchers in the United States report. "The addition of Ii-Key, a four-amino-acid LRMK modification, increases vaccine potency when compared with unmodified class II epitopes. We present the results of the first human phase I trial of the Ii-Key hybrid HER-2/neu peptide (AE37) vaccine in disease-free, node-negative breast cancer patients. Patients and Methods The dose escalation trial included five dose groups, to determine safety and optimal dose of the hybrid peptide (100 mu g, 500 mu g, 1,000 mu g)...
Source: Cancer Weekly (2008-09-02)
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