Cancer Weekly
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Gene Therapy
New gene therapy findings from Z.H. Zhang and co-researchers published
September 2nd, 2008
"Use of the herpes simplex virus thymidine kinase gene/ ganciclovir (HSV-tk/GCV) system is one of the promising approaches in the rapidly growing area of gene therapy. The ''bystander effect,'' a phenomenon in which HSV-tk(+) cells exposed to GCV are toxic to adjacent HSV-tk(-) cells, was reported to play an important role in suicide gene therapy," scientists in Wuhan, People's Republic of China report. "However, the mechanism by which HSV-tk/GCV induces the bystander effect is poorly understood. We monitored the activation of caspase-3 in living cells induced by the HSV-tk/GCV system using a genetically encoded fluorescence resonance energy transfer (FRET) probe CD3, a...
Source: Cancer Weekly (2008-09-02)
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