Cancer Weekly
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Gene Therapy
Recent studies from Brain Tumor Center add new data to gene therapy
September 2nd, 2008
According to recent research published in the Journal of Medical Virology, "Malignant glioma, in particular glioblastoma multiforme (GBM), represents one of the most devastating cancers currently known and existing treatment regimens do little to change patient prognosis. Conditionally replicating adenoviral vectors (CRAds) represent attractive experimental anti-cancer agents with potential for clinical application." "However, early protein products of the wild type adenovirus backbone-such as E1A-limit CRAds' replicative specificity. In this study, we evaluated the oncolytic potency and specificity of CRAds in which p300/CPB and/or pRb binding capacities of E1A...
Source: Cancer Weekly (2008-09-02)
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