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Stem Cell Research
Treatment with Plerixafor Shown to Improve Mobilization of Cells in Donors During Bone Marrow Stem Cell Collection Procedures
September 2nd, 2008
In a study of 25 bone marrow donors, treatment with plerixafor, an antagonist able to disrupt a critical pathway associated with stem cell mobilization, was shown to mobilize cells faster than treatment with granular colony-stimulating factor (G-CSF), the current standard method used to collect bone marrow stem cells from healthy donors. According to the study results, two-thirds of donors treated with plerixafor were shown to mobilize a sufficient number of cells for transplantation after only one day. Donors treated with G-CSF require four to five days of treatment before collection is initiated. Results of the study are reported in the peer-review publication Blood....
Source: Cancer Weekly (2008-09-02)
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