Published in Cancer Weekly, September 2nd, 2008
"We hypothesized that the complementary inhibition of VEGF signaling would have synergistic therapeutic effects. Patients and Methods Patients had advanced solid tumors, Eastern Cooperative Oncology Group performance status of 0 to 1, and good end-organ function. A phase I dose-escalation trial of sorafenib and bevacizumab was initiated at below-recommended single-agent doses because of possible overlapping toxicity: sorafenib 200 mg orally twice daily...
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