Cancer Weekly
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Angiogenesis
Recent findings in angiogenesis described by researchers from University of Florida, Medical Department
September 2nd, 2008
"The development of intratumoral hypoxia is a universal hallmark of rapidly growing solid tumors. Adaptation to the hypoxic environment, which is critical for tumor cell survival and growth, is mediated primarily through a hypoxia-inclucible factor (HIF)dependent transcriptional program," scientists in the United States report. "HIF activates genes that facilitate crucial adaptive mechanisms including increased glucose uptake and glycolysis and tumor angiogenesis, making it an important therapeutic target. However, the HIF-dependent transcriptional mechanism remains incompletely understood, and targeting HIF is a difficult endeavor. Here, we show that the orphan nuclear...
Source: Cancer Weekly (2008-09-02)
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