Cancer Weekly
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Angiogenesis
Researchers from INSERM report details of new studies and findings in the area of angiogenesis
September 2nd, 2008
"Vascularization is an important step in tumour growth. Although a variety of molecules, for example, VEGF, ETS-1 or nestin have been implicated in tumour angiogenesis, the molecular mechanisms of vessel formation are not fully characterized," researchers in Nice, France report. "We showed that the Wilms' tumour suppressor WT1 activates nestin during development. Here we tested whether WT1 might also be involved in tumour angiogenesis. Endothelial WT1 expression was detected in 95% of 113 tumours of different origin. To analyse the function of WT1 in endothelial cells, we used an RNAi approach in vitro and showed that inhibition of WT1 reduces cell proliferation,...
Source: Cancer Weekly (2008-09-02)
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