Cancer Weekly
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Angiogenesis
Studies from University of Helsinki add new findings in the area of angiogenesis
September 2nd, 2008
"Prostate-specific antigen (PSA or KLK3) has been shown to inhibit angiogenesis, but it might also have tumor promoting activities. Thus, it may be possible to modulate prostate cancer growth by stimulating or inhibiting the activity of PSA," scientists writing in the journal Prostate report. "To this end we have previously identified peptides that stimulate the activity of PSA. As peptides have several limitations as drug molecules, we screened a chemical library to find drug-like compounds that could be used to modulate the function(s) of PSA. Almost 50,000 compounds were analyzed for their ability to modulate PSA activity towards a fluorescent PSA-substrate....
Source: Cancer Weekly (2008-09-02)
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