Cancer Weekly
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Apoptosis
Reports outline apoptosis research from J. Bakhshi and colleagues
September 2nd, 2008
According to recent research from the United States, "The microenvironment of cancerous cells includes endoplasmic reticulum ( ER) stress the resistance to which is required for the survival and growth of tumors. Acute ER stress triggers the induction of a family of ER stress proteins that promotes survival and/or growth of the cancer cells, and also confers resistance to radiation and chemotherapy." "Prolonged or severe ER stress, however, may ultimately overwhelm the cellular protective mechanisms, triggering cell death through specific programmed cell death (pcd) pathways. Thus, downregulation of the protective stress proteins may offer a new therapeutic approach to...
Source: Cancer Weekly (2008-09-02)
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