Cancer Weekly
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Apoptosis
Research findings from Tzu Chi University update understanding of apoptosis
September 2nd, 2008
"The objective of this study was to evaluate the cardiac toxicity induced by carboplatin, a second generation platinum-containing anti-cancer drug, and to test whether pravastatin can reduce this cardio-toxicity. In the present study, infusion of carboplatin (100 mg/kg) to mice resulted in decreased survival rates and abnormal cardiac histology, concomitant with increased cardiac apoptosis," researchers in Hualien, Taiwan report. "In addition, treatment of cultured rat cardiomyocytes with carboplatin (100 mc M for 48 h) caused marked apoptosis and increased caspase-3, -9, and cytochrome C, but decreased BCL-XL protein expression, and this was inhibited by reactive...
Source: Cancer Weekly (2008-09-02)
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