Sarcoma

Studies from East Carolina University, Medical Department further understanding of sarcoma

Published in Cancer Weekly, September 2nd, 2008

According to recent research published in the journal Cellular Microbiology, "Kaposi's sarcoma-associated herpesvirus (KSHV) has two modes of replications: latent and lytic replications. Reactivation from latency is dictated, in part, by the cell cycle."

"Herein, we have attempted to delineate the importance of cell cycle in KSHV pathogenesis by exploring the expression pattern of cell-surface receptors during different phases of the cell cycle. alpha V integrin expression is augmented during S phase in fibroblasts, epithelial and KSHV-infected cells. Using a Matrigel system, we pioneer the concept that KSHV-infected primary effusion lymphoma cells can attach to...

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Source: Cancer Weekly (2008-09-02)

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