Cancer Weekly
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Basal Cell Cancer
New basal cell cancer research from University of Rochester described
September 2nd, 2008
According to recent research published in the journal Clinical Cancer Research, "In superficial basal cell carcinomas treated with photodynamic therapy with topical delta-aminolevulinic acid, we examined effects of light irradiance on photodynamic efficiency and pain. The rate of singlet-oxygen production depends on the product of irradiance and photosensitizer and oxygen concentrations." "High irradiance and/or photosensitizer levels cause inefficient treatment from oxygen depletion in preclinical models. Self-sensitized photobleaching of protoporphyrin IX (PpIX) fluorescence was used as a surrogate metric for photodynamic dose. We developed instrumentation...
Source: Cancer Weekly (2008-09-02)
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