Cancer Weekly
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Cancer Vaccines
New findings from National Institutes of Health in the area of cancer vaccines described
September 2nd, 2008
"Nonmutated tissue differentiation antigens expressed by tumors are attractive targets for cancer immunotherapy, but the consequences of a highly effective antitumor immune response on self-tissue have not been fully characterized. We found that the infusion of ex vivo expanded adoptively transferred melanoma/melanocyte-specific CD8(+) T cells that mediated robust tumor killing also induced autoimmune destruction of melanocytes in the eye," scientists in the United States report. "This severe autoimmunity was associated with the upregulation of MHC class I molecules in the eye and high levels of IFN-gamma derived-from both adoptively transferred CD8(+) T cells and host...
Source: Cancer Weekly (2008-09-02)
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