Cancer Weekly
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Cancer Vaccines
Researchers from Mie University, Medical Department report recent findings in cancer vaccines
September 9th, 2008
"We previously found that a Salmonella typhimurium vector engineered to secrete soluble tumor antigen induces CD4(+) T cells resistant to CD4(+)CD25(+) regulatory T cells (Treg) and that glucocorticoid-induced tumor necrosis factor receptor familyrelated gene (GITR) signal is involved in the development of this resistance. In this study, we address the potential of incorporating GITR ligand (GITRL) as a way to augment the immunogenicity of cancer vaccines," investigators in Tsu, Japan report. "BALB/c mice were immunized by gene gun with plasmids encoding the mutated extracellular signal-regulated kinase 2 (mERK) with or without plasmids encoding mouse GITRL....
Source: Cancer Weekly (2008-09-09)
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