Cancer Weekly
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Osteosarcoma
Study results from Uppsala University provide new insights into osteosarcoma
September 9th, 2008
"We assessed T-cell responses in young osteosarcoma patients vaccinated with 105AD7, 1-6months after having received chemotherapy. 105AD7 is a human anti-idiotypic antibody mimicking CD55, a glycoprotein that protects from attack by complement and which is overexpressed on osteosarcoma cells. Seven out of 21 investigated patients made a IFN-gamma T-cell response against the vaccine, 105AD7 as assessed by ELISPOT," scientists in Uppsala, Sweden report. "Cytokine secretion was analysed using Luminex assays and revealed TNF-alpha and GM-CSF responses not only to the vaccine but also towards the native antigen, CD55, in 5 / 14 (36%) of investigated patients. Importantly,...
Source: Cancer Weekly (2008-09-09)
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