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Cancer Vaccines
Data on cancer vaccines described by researchers at University of Southampton, Cancer Sciences Division
September 9th, 2008
Investigators publish new data in the report 'DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire.' "The majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets," scientists in Southampton, the United Kingdom report. "Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4(+) T cell help. Candidate MHC class I-binding...
Source: Cancer Weekly (2008-09-09)
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