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Enzyme Research
Research from M. Ganzinelli and co-authors provides new data about enzyme research
September 9th, 2008
New research, 'Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil,' is the subject of a report. According to a study from Milan, Italy, "After DNA damage, checkpoints pathways are activated in the cells to halt the cell cycle, thus ensuring repair or inducing cell death. To better investigate the role of checkpoint kinase 1 (Chk1) in cellular response to different anticancer agents, Chk1 was knocked down in HCT-116 cell line and in its p53-deficient subline by using small interfering RNAs (siRNA)." "Chk1 was abrogated by transient transfection of specific siRNA against...
Source: Cancer Weekly (2008-09-09)
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