Cancer Weekly
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Angiogenesis
Research from University of Maastricht provide new insights into angiogenesis
September 9th, 2008
"Sustained proinflammatory responses in rheumatoid arthritis, atherosclerosis, and diabetic retinopathy, as well as in cancer, are often associated with increased angiogenesis that contributes to tissue disruption and disease progression. High mobility group B1 (HMGB1) has been recognized as a proinflammatory cytokine and more recently, as a proangiogenic factor," researchers in Netherlands report. "HMGB1 can either be passively released from necrotic cells or actively secreted in response to angiogenic and inflammatory signals. HMGB1 itself may signal through the receptor for advanced glycation end products ( RAGE), and via toll-like receptors, TLR2 and TLR4....
Source: Cancer Weekly (2008-09-09)
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