Cancer Weekly
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Angiogenesis
Research in the area of angiogenesis reported from University of Tokyo, Medical Department
September 9th, 2008
"The Hedgehog family of proteins are powerful morphogens mediating embryonic development as well as adult morphogenesis and carcinogenesis. For example, excess hedgehog activity has been implicated in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma," scientists in Hongo, Japan report. "More recently, hedgehog signalling has been implicated in angiogenesis. While hedgehog signalling in adult angiogenesis may constitute a simple recapitulation of that in embryonic development, it should be appreciated that Hedgehog signalling occurs in embryonic angiogenesis in different developmental contexts. This article reviews the role of Hedgehog signalling in both...
Source: Cancer Weekly (2008-09-09)
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