Cancer Weekly
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Cancer Gene Therapy
Investigators at University of Padua release new data on cancer gene therapy
September 9th, 2008
"The side population (SP), recently identified in several normal tissues and in a variety of tumors based on its ability to extrude some fluorescent dyes, may comprise cells endowed with stem cell features. In this study, we investigated the presence of SP in epithelial ovarian cancer and found it in 9 of 27 primary tumor samples analyzed, as well as in 4 of 6 cultures from xenotransplants," researchers in Padua, Italy report. "SP cells from one xenograft bearing a large SP fraction were characterized in detail. SP cells had higher proliferation rates, were much less apoptotic compared with non-SP cells, and generated tumors more rapidly than non-SP cells. We also...
Source: Cancer Weekly (2008-09-09)
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