Cancer Weekly
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Apoptosis
Research on apoptosis described by scientists at University of Modena
September 9th, 2008
"Cells lacking mitochondrial genome (defined as rho(0)) are useful models in studies on cancer, aging, mitochondrial diseases and apoptosis, but several of their functional aspects have been poorly characterized. Using different clones of rho(0) cells derived from the human osteosarcoma line 143B, we have tested the effects of different apoptogenic molecules such as staurosporine (STS), doxorubicin, daunomycin and quercetin, and have analyzed apoptosis, mitochondrial membrane potential (NIMP), levels of oxygen free radicals, reduced glutathione (GSH) content, and expression of P-glycoprotein (P-gp)," scientists in Modena, Italy report. "When compared to parental cells,...
Source: Cancer Weekly (2008-09-09)
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