Cancer Weekly
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Apoptosis
Research on apoptosis detailed by scientists at Hiroshima University
September 9th, 2008
According to a study from Japan, "Peroxisome proliferator-activated receptor gamma (PPAR gamma) ligands inhibit cell growth and induce apoptosis in various cancer cells. Bile acids are also known to cause hepatocyte apoptosis through nuclear receptor-mediated mechanisms." "The aim of this study was to examine the effect of two different bile acid species on the inhibitory action of PPAR gamma in cell growth with paying attention to the role of the mitogen-activated protein kinase pathway as an underlying mechanism. Immortalized human hepatocytes (OUMS-29) and hepatoma cells (HepG2 and Huh7) were incubated with troglitazone (TGZ), a PPAR gamma ligand with or without...
Source: Cancer Weekly (2008-09-09)
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