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Apoptosis
Scientists at Shenyang Pharmaceutical University publish research in apoptosis
September 9th, 2008
"The redox environment of the cell is currently thought to be extremely important to control either apoptosis or autophagy. This study reported that reactive oxygen species (ROS) and nitric oxide (NO) generations were induced by evodiamine time-dependently; while they acted in synergy to trigger mitochondria-dependent apoptosis by induction of mitochondrial membrane permeabilization (MMP) through increasing the Bax/Bcl-2 or Bcl-x(L) ratio," scientists writing in the journal Free Radical Research report. "Autophagy was also stimulated by evodiamine, as demonstrated by the positive autophagosome-specific dye monodansylcadaverine (MDQ staining as well as the...
Source: Cancer Weekly (2008-09-09)
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