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Cancer Gene Therapy
Studies from Fraunhofer Institute of Toxicology and Experimental Medicine in the area of cancer gene therapy published
September 16th, 2008
Investigators publish new data in the report 'Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation.' "c-raf is a serine-threonine kinase and a downstream effector of ras signaling. This kinase plays an essential role in cell proliferation, differentiation, and apoptosis," scientists in Hannover, Germany report. "In the past, we reported induction of c-raf gene expression in rat liver cancer on treatment with a mixture of aryl hydrocarbon receptor (AhR) agonists. This prompted our interest in investigating the role of AhR in the transcriptional regulation of c-raf....
Source: Cancer Weekly (2008-09-16)
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