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DNA Research
Studies from New York University, Department of Oncological Sciences have provided new data on DNA research
September 16th, 2008
Investigators publish new data in the report 'Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN.' "In this study, we show that depletion of Chk1 by small interfering RNA (siRNA) results in failure of reentry to the cell cycle after DNA replication has been stalled by exposure to hydroxyurea (HU). Casein kinase II (CKII) is degraded in these cells in a proteasome-dependent manner, resulting in decreased phosphorylation and PTEN levels," scientists in the United States report. "We show that phosphorylation of Chk1 at Ser(317) but not at Ser(345) is required for phosphorylation of PTEN at...
Source: Cancer Weekly (2008-09-16)
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