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Gene Therapy
New gene therapy findings from Center for Biomedical Genetics described
September 16th, 2008
New investigation results, 'The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions,' are detailed in a study published in Cellular Signalling. "The small G-protein Rap1 is a critical regulator of cell-cell contacts and is activated by the remodeling of adherens junctions. Here we identify the Rap1 guanine nucleotide exchange factor PDZ-GEF2 as an upstream activator of Rap1 required for the maturation of adherens junctions in the lung carcinoma cells A549," scientists writing in the journal Cellular Signalling report. "Knockdown of PDZ-GEF2 results in the persistence of adhesion zippers at cell-cell contacts. Activation of Rap1A rescues...
Source: Cancer Weekly (2008-09-16)
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