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Osteosarcoma Gene Therapy
St. Vincent's Hospital, Department of Orthopaedics publishes research in osteosarcoma gene therapy
September 16th, 2008
Research findings, 'c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model,' are discussed in a new report. According to a study from Melbourne, Australia, "The oncogene c-Jun has been found to be up-regulated in a variety of cancers including osteosarcoma." "DNA enzymes (DNAzymes) are oligonucleotides capable of specific catalysis of target mRNA. A c-Jun DNAzyme inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasizing model of the disease. c-Jun down-regulation-mediated apoptosis in osteosarcoma cells involved caspase-1, caspase-2, and caspase-8, but not the Fas/FasL...
Source: Cancer Weekly (2008-09-16)
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