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Solid Cancer Gene Therapy
Researchers from Duke University, Department of Biomedical Engineering publish findings in solid cancer gene therapy
September 16th, 2008
Scientists discuss in 'Relaxin treatment of solid tumors: effects on electric field-mediated gene delivery' new findings in solid cancer. According to recent research from the United States, "Pulsed electric fields have been shown to enhance interstitial transport of plasmid DNA (pDNA) in solid tumors in vivo. However, the extent of enhancement is still limited partly due to the collagen component in extracellular matrix." "To this end, effects of collagen remodeling on interstitial electrophoresis were investigated by pretreatment of tumor-bearing mice with a recombinant human relaxin (rh-Rlx). In the study, two tumor lines (4T1 and B16.F10) were examined and implanted...
Source: Cancer Weekly (2008-09-16)
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