Cancer Weekly
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Acute Myeloid Leukemia
Reports from N.A. Ellis and co-researchers add new data to research in acute myeloid leukemia
September 16th, 2008
According to recent research published in the journal Blood, "The p53 tumor suppressor directs the cellular response to many mechanistically distinct DNA-damaging agents and is selected against during the pathogenesis of therapy-related acute myeloid leukemia (t-AML). We hypothesized that constitutional genetic variation in the p53 pathway would affect t-AML risk." "Therefore, we tested associations between patients with t-AML (n = 171) and 2 common functional p53-pathway variants, the MDM2 SNP309 and the TP53 codon 72 polymorphism. Although neither polymorphism alone influenced the risk of t-AML, an interactive effect was detected such that MDM2 TT TP53 Arg/Arg...
Source: Cancer Weekly (2008-09-16)
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