Cancer Weekly
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Angiogenesis
Report summarizes angiogenesis study findings from University of Wurzburg
September 16th, 2008
According to recent research from Wurzburg, Germany, "Vascular endothelial growth factor (VEGF) promotes breast cancer progression by inducing angiogenesis via VEGF receptors on endothelial cells but also signals directly through receptors such as VEGFR-1 (Flt-1) expressed on tumour cells. The impact of autocrine signalling loops on treatment with VEGF inhibitors is still unclear." "Six breast cancer cell lines were tested for expression of VEGFR-1 by RT-PCR and Western blot. To assess clinical significance, 93 breast cancer lesions were evaluated for expression of VEGF and VEGFR-1 by immunohistochemistry. VEGFR-1 mRNA was found in all 6 cell lines, while protein...
Source: Cancer Weekly (2008-09-16)
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