Cancer Weekly
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Apoptosis
Reports summarize apoptosis study results from Harvard University
September 16th, 2008
"Stimulation of the death receptor superfamily induces the activation of caspase-8 and thereby the apoptotic response. The MUCI oncoprotein is aberrantly overexpressed by diverse human malignancies and inhibits stress-induced apoptosis," scientists in the United States report. "The present results show that MUCI blocks activation of caspase-8 and apoptosis in the response of malignant cells to tumor necrosis factor cy, tumor necrosis factor-related apoptosis-inducing ligand, and Fas ligand. The results show that MUCI associates constitutively with caspase-8. The MUCI cytoplasmic domain (MUCI-CD) binds directly to the caspase-8 p18 fragment upstream to the catalytic Cys...
Source: Cancer Weekly (2008-09-16)
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