Cancer Weekly
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Apoptosis
Research results from Y.H. Ma and co-authors update knowledge of apoptosis
September 16th, 2008
According to recent research published in the journal Cancer Research, "HLM006474 was identified using a computer-based virtual screen and the known crystal structure of the DNA-bound E2F4/DP2 heterodimer. Treatment of multiple cell lines with HLM006474 resulted in the loss of intracellular E2F4 DNA-binding activity as measured by electrophoretic mobility shift assay within hours." "Overnight exposure to HLM006474 resulted in down-regulation of total E2F4 protein as well as known E2F targets. The effects of HLM006474 treatment on different cell lines varied but included a reduction in cell proliferation and an increase in apoptosis. HLM006474 induced apoptosis in...
Source: Cancer Weekly (2008-09-16)
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