Cancer Weekly
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Atherosclerosis
Research on atherosclerosis detailed by scientists at Showa Pharmaceutical University
September 16th, 2008
"PPAR gamma regulates the expression of numerous genes. In addition to their anti-diabetic activity, PPAR gamma agonists have been reported to have beneficial effects for cancer, inflammation including inflammatory bowel disease, atherosclerosis and brain inflammation, as well as bone turnover," investigators in Tokyo, Japan report. "To investigate a potential new class of ligands for PPAR gamma, we designed with reference to the crystal structure of the ligand-binding domain of PPAR gamma oxidized docosahexaenoic acid (DHA) derivatives, which have a hydrophilic substituent at the C(4)-position and are putative metabolites of DHA. We synthesized 14 compounds and...
Source: Cancer Weekly (2008-09-16)
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