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Basal Cell Cancer
Study findings from University of Basel broaden understanding of basal cell cancer
September 16th, 2008
According to recent research from Basel, Switzerland, "Mutations in the Hedgehog signaling pathway is responsible for the formation of various cancers, including some forms of basal cell carcinoma (BCC). Uncontrolled Hedgehog signaling leads to overexpression of the zinc finger Gli transcription factors, among which Gli2 plays a central role." "We found that high Gli2 expression induced the concomitant high expression of the caspase 8 inhibitor, cFlip, and thereby counteracts death-ligand-mediated apoptosis. By investigating the cFlip promoter, Gli2 binding sites were identified and confirmed. Gli2 gene silencing by RNA interference broke the apoptosis resistance via...
Source: Cancer Weekly (2008-09-16)
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