Cancer Weekly
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Bladder Cancer
Data on bladder cancer described by L. Fontana et al
September 16th, 2008
According to recent research from Clermont-Ferrand, France, "In polygenic diseases, association studies look for genetic variation such as polymorphisms in low penetrance genes, i.e. genes in interaction with environmental factors. DNA repair systems that protect the genome from deleterious endogenous and exogenous damage have been shown to significantly reduce activity." "In particular, enzymes of the nucleotide excision repair pathway are suspected to be implicated in cancer. In this study bladder cancer which is viewed as a polygenic disease was investigated. The functional polymorphisms of four DNA repair genes, excision repair cross-complementing group 2 (ERCC2),...
Source: Cancer Weekly (2008-09-16)
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