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Bladder Cancer
Study data from A. Choudhury et al provide new insights into bladder cancer
September 16th, 2008
According to recent research from Leeds, the United Kingdom, "Chemicals from occupational exposure and components of cigarette smoke can cause DNA damage in bladder urothelium. Failure to repair DNA damage by DNA repair proteins may result in mutations leading to genetic instability and the development of bladder cancer." "Immunohistochemistry studies have shown DNA damage signal activation in precancerous bladder lesions which is lost on progression, suggesting that the damage signalling mechanism acts as a brake to further tumorigenesis. Single nucleotide polymorphisms (SNPs) in DSB signalling genes may alter protein function. We hypothesized that SNPs in DSB...
Source: Cancer Weekly (2008-09-16)
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