Cancer Weekly
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Gene Therapy
New research on gene therapy from A. Lorico and co-authors summarized
September 23rd, 2008
"Despite recent technical improvements in surgical excision techniques and adjuvant radio- and chemotherapy, the clinical outcome of patients with grade IV astrocytoma ( glioblastoma) remains very poor, with a median survival of less than 12 months. A promising approach to therapy employs gene-engineered neural stem/progenitor cells ( NSCs) as a cellular therapeutic delivery system, to track glioblastoma cells and deliver anticancer molecules," scientists in the United States report. "However, most results on their tumor tropism have been derived by immortalized NSCs. We now report that primary murine gene-engineered NSCs displayed in vivo tropism for glioblastoma...
Source: Cancer Weekly (2008-09-23)
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