Cancer Weekly
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Gene Therapy
Researchers from INSERM report recent findings in gene therapy
September 23rd, 2008
According to recent research from Evry, France, "We previously demonstrated that the switch from non- to highly tumorigenic phenotype of human melanoma cells is directly related to procathepsin L secretion, which increased cell resistance to complement-mediated cell lysis. Involvement of procathepsin L secretion in tumor growth was clearly demonstrated by three different strategies: ( 1) inhibition of secreted procathepsin L activity; ( 2) increase of procathepsin L secretion; and ( 3) inhibition of procathepsin L secretion." "This latter strategy was triggered by intracellular expression of anti-human cathepsin L single-chain variable fragment ( ScFv). These previous...
Source: Cancer Weekly (2008-09-23)
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