Cancer Weekly
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Gene Therapy
Studies from University of Kuopio reveal new findings on gene therapy
September 23rd, 2008
According to recent research from Kuopio, Finland, "Targeting viral entry is one of the major goals in the development of vectors for gene therapy. Ideally, the coupling of each new targeting motif would not require changes in vector structure." "To achieve this, we developed novel metabolically biotinylated baculoviral vectors by displaying a small biotin acceptor peptide (BAP) fused either to different sites in the baculovirus glycoprotein gp64 or to the transmembrane anchor of vesicular stomatitis virus G protein. Baculoviral particles were biotinylated during vector production by coexpression of Escherichia coli biotin ligase (BirA). The insertion of BAP at amino...
Source: Cancer Weekly (2008-09-23)
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