Immunotherapy

Research from W. Gong and co-authors reveals new findings on immunotherapy

Published in Cancer Weekly, September 23rd, 2008

According to a study from Wuhan, People's Republic of China, "Immunotherapy can effectively suppress tumor, yet complete tumor eradication occurs infrequently. The metastatic potential of remnant tumor cells after immunotherapy and the underlying mechanisms have not been fully elucidated."

"Here, we report that the termination of immunotherapy strikingly increases the metastatic potential of remnant melanoma. This is mainly due to the withdrawal of IFN-gamma after immunotherapy. The relief of IFN-gamma stress led to the increase of alpha v beta 3 integrin expression in B16 cells, which increased the adhesion of B16 cells to fibrinogen, fibronectin and laminin. Through...

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Source: Cancer Weekly (2008-09-23)

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