Life Sciences

Reports summarize life sciences study results from University of Texas

Published in Cancer Weekly, September 23rd, 2008

According to a study from the United States, "Human G protein-coupled receptor 30 (GPR30) mediates estradiol-17 beta (E2) activation of adenylyl cyclase in breast cancer cells and displays E2 binding typical of membrane estrogen receptors (mERs). We identified a mER in Atlantic croaker ovaries with characteristics similar to those of human GPR30."

"To confirm the proposed role of GPR30 as a mER in this distantly related vertebrate group, we cloned GPR30 from croaker ovaries and examined its distribution, steroid binding, and signaling characteristics. Western blot analysis showed the GPR30 protein (similar to 40 kDa) is expressed on the plasma membranes of croaker...

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Source: Cancer Weekly (2008-09-23)

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