Cancer Weekly
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Cancer Vaccines Immunology
Scientists at Medical University of South Carolina detail research in cancer vaccines immunology
September 23rd, 2008
Researchers detail in 'Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma,' new data in cancer vaccines. According to recent research from the United States, "HLA class II-restricted antigen (Ag) processing and presentation are important for the activation of CD4+ T cells, which are the central orchestrating cells of immune responses. The majority of melanoma cells either expresses, or can be induced to express, HLA class II proteins." "Thus, they are prime targets for immune mediated elimination by class II-restricted CD4+ T cells. We have previously shown that human melanoma cells lack an important...
Source: Cancer Weekly (2008-09-23)
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