Cancer Weekly
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Adenocarcinoma
Study results from Sutcu Imam University, Medical Department update understanding of adenocarcinoma
September 23rd, 2008
According to recent research from Kahramanmaras, Turkey, "CDX2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestine. In this study, we examined CDX2 expression in normal and neoplastic human colon using a newly isolated monoclonal antibody." "When compared to the intensity observed in adjacent normal mucosal epithelial cells, strong nuclear staining for CDX2 was observed in 10 (100%) of 10 colonic adenomas, 30 (88.2%) of 34 colorectal adenocarcinomas, including 17(94.47%) of 18 well-or moderately differentiated tumors and 13(81.2%) of 16 high-grade tumors. The percentage of CDX2 immunopositive...
Source: Cancer Weekly (2008-09-23)
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