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Cancer Therapy

Studies from University of Arizona, Arizona Cancer Center yield new information about cancer therapy

Published in Cancer Weekly, September 23rd, 2008

A new study, 'Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress,' is now available. According to recent research from the United States, "Strong experimental evidence suggests the involvement of photo-oxidative stress mediated by reactive oxygen species as a crucial mechanism of solar damage relevant to human skin photoaging and photocarcinogenesis. Based on the established role of antioxidant response element (ARE)-mediated gene expression in cancer chemoprevention, we tested the hypothesis that small molecule Nrf2-activators may serve a photo-chemopreventive role by targeting skin cell photo-oxidative stress."

"A luciferase-based...

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