Cancer Weekly
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Cancer Vaccines
Research on cancer vaccines discussed by R.J. Amato and co-researchers
September 23rd, 2008
"The attenuated vaccinia virus, modified vaccinia Ankara, has been engineered to deliver the tumor antigen 5T4 (TroVax). TroVax has been evaluated in an open-label phase 2 trial in hormone refractory prostate cancer patients in which the vaccine was administered either alone or in combination with granulocyte macrophage-colony stimulating factor (GM-CSF)," scientists in the United States report. "The comparative safety and immunologic and clinical efficacy of TroVax alone or in combination with GM-CSF was determined. Twenty-seven patients with metastatic hormone refractory prostate cancer were treated with TroVax alone (n = 14) or TroVax + GM-CSF (n 13). 5T4-specific...
Source: Cancer Weekly (2008-09-23)
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