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Roche Diagnostics
Heritable Mutations of ALK Main Cause of Familial Neuroblastoma
September 30th, 2008
Germline mutations in the anaplastic lymphoma kinase (ALK) gene explain most hereditary neuroblastomas, providing the first example of a pediatric cancer arising because of mutations in an oncogene, as a recent published research study has shown (1). Together with the reported common variations at chromosome band 6p22 predisposing to the development of sporadic neuroblastoma (2), the genetic etiology of this disease, one of the most common childhood tumors, has now being defined and has clearly established ALK as a critical neuroblastoma oncogene. Yael Mosse and co-workers, from Philadelphia/PA, USA, studied twenty probands with neuroblastoma and a family history of the...
Source: Cancer Weekly (2008-09-30)
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