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Gene Therapy
University College, University College of London details research in gene therapy
September 30th, 2008
A report, 'Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients,' is newly published data in The Journal of Clinical Investigation. "X-linked SCID (SCID-X1) is amenable to correction by gene therapy using conventional gammaretroviral vectors. Here, we describe the occurrence of clonal T cell acute lymphoblastic leukemia (T-ALL) promoted by insertional mutagenesis in a completed gene therapy trial of 10 SCID-X1 patients," researchers in London, the United Kingdom report. "Integration of the vector in an antisense orientation 35 kb upstream of the protooncogene LIM domain only 2 (LMO2)...
Source: Cancer Weekly (2008-09-30)
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