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Neuroblastoma Gene Therapy
Research conducted at Chiba Cancer Center Research Institute, Division of Biochemistry has provided new information about neuroblastoma gene therapy
September 30th, 2008
New research, 'KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death,' is the subject of a report. According to recent research from Chiba, Japan, "Deletion of the distal region of chromosome 1 frequently occurs in a variety of human cancers, including aggressive neuroblastoma. Previously, we have identified a 500-kb homozygously deleted region at chromosome 1p36.2 harboring at least six genes in a neuroblastoma-derived cell line NB1/C201." "Among them, only KIF1Bbeta, a member of the kinesin superfamily proteins, induced apoptotic cell death. These results prompted us to address whether KIF1Bbeta...
Source: Cancer Weekly (2008-09-30)
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